Successful management of adult hemophagocytic lymphohistiocytosis with an etoposide-containing regimen: Case report and literature review
نویسندگان
چکیده
Objective: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder characterized by hyperimmune response. Although HLH well described in the pediatric population, less known about appropriate management adults. Despite inclusion of etoposide society protocols, some clinicians refrain from using it due to its cytotoxicity and potential adverse effects. Case: We report here case 43-year-old male presenting with fever pancytopenia, who was diagnosed following further evaluation. The patient immediately started HLH-2004 initial protocol, which consisted dexamethasone, etoposide, cyclosporine, IVIG. Symptoms improved after 2 weeks treatment. Subsequent bone marrow biopsy showed normal results, achieved complete remission, leading termination treatment 12th week protocol. At 8 months post-treatment, remained recurrence-free hematological biochemical test results. Conclusion: This underscores importance considering etoposide-containing regimens, particularly for medically fit patients.
منابع مشابه
Histoplasmosis-Induced Hemophagocytic Lymphohistiocytosis in an Adult Patient: A Case Report and Review of the Literature
Hemophagocytic lymphohistiocytosis (HLH) is an aggressive and life-threating immune dysregulation syndrome characterized by persistent activation of the mononuclear phagocytic system leading to uncontrolled systemic hyperinflammatory response. The proliferation and activation of histiocytes and lymphocytes lead to production of large amounts of cytokines, also called cytokine storm. Hematopoiet...
متن کاملDengue-associated hemophagocytic lymphohistiocytosis in an adult: A case report and literature review: Erratum
BACKGROUND Infection-associated hemophagocytic syndrome (IAHS) is potentially a fatal disease caused by systemic infection complicated by hemophagocyticlymphohistiocytosis (HLH). Here, we report a case of HLH associated with dengue hemorrhagic fever (DHF) after a trip to Thailand. CASE SUMMARY A 33-year-old healthy female patient presented with 3 days of fever, myalgia, and skin rash. Serotyp...
متن کاملLiver transplant for adult hemophagocytic lymphohistiocytosis: case report and literature review.
We report the case of a middle-aged man who died from multiorgan failure 3 weeks after orthotopic liver transplant for fulminant hepatic failure, associated with a rare, often fatal, hematologic condition that usually presents in childhood. We discuss the importance of its diagnosis, treatment, and implications for liver transplant.
متن کاملSuccessful Treatment of Herpes Simplex Virus (HSV)-1-associated Hemophagocytic Lymphohistiocytosis (HLH) with Acyclovir: A Case Report and Literature Review
Hemophagocytic lymphohistiocytosis (HLH) associated with herpes simplex virus (HSV)-1 infection (HSV-1-HLH) is uncommon and is potentially fatal without appropriate treatment. We herein report the case of an adult patient with HSV-1-HLH who was successfully treated with acyclovir. A 69-year-old man developed fever, pancytopenia and liver enzyme elevation after the resolution of pneumonia. These...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Medical Science and Discovery
سال: 2023
ISSN: ['2148-6832']
DOI: https://doi.org/10.36472/msd.v10i7.975